If you want to be close to the big historic sights, the Centro Histórico puts you within walking distance of the Zócalo, the Templo Mayor ruins, and the Palacio de Bellas Artes, with excellent metro connections for getting anywhere else cheaply. It's a lively, crowded area by day, so keep the usual city-travel awareness in mind, especially after dark.
Roma Norte and Condesa offer a completely different pace — tree-lined streets, Art Deco buildings, parks, and no shortage of good coffee and mezcal bars. Both neighbourhoods are popular with visitors and easy to get around on foot or by bike. Our hotel booking guide can help you think through what matters most for your trip.